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Year : 2020  |  Volume : 6  |  Issue : 1  |  Page : 1-7

The role of estrogen receptors α, β, γ in oral squamous cell carcinoma and a comparative perspective of squamous cell carcinoma

1 Department of Oral Pathology and Microbiology, Nanded Rural Dental College, Nanded, Maharashtra, India
2 Department of Oral Pathology and Microbiology, Sharad Pawar Dental College and Hospital, Sawangi, Wardha, Maharashtra, India
3 Department of Dentistry, Indira Gandhi Medical College and Hospital, Nagpur, Maharashtra, India

Correspondence Address:
Dr. Eesha Thakare
Shiv Multispeciality Dental Clinic, Akshay Plaza, Opposite Janata Bank, Jatharpeth, Akola - 444 005, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijohr.ijohr_3_20

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The “nuclear receptors” (NRs) belong to the huge group of transcription factors, triggered with the help of diverse signal molecules. Various physiological (or pathological) conditions responding to metabolite, hormonal, and nutrient signals lead to the activation of specific gene expression with the help of large number of members of NR superfamily. The role of hormone estrogen as an oncogenic agent is well illustrated in hormone-sensitive carcinomas that include ovarian, colon, endometrial, prostate, lung, and breast. This is the first review on oral squamous cell carcinoma (OSCC) pertaining to Estrogen receptors (ER) like α, β and γ study published in PubMed. For hormone ligand action in head and neck carcinomas (HNCs) specifically, experiments in vivo and in vitro studies support a probable biological mechanism. As per the search in PubMed (search words ERs, OSCC, HNCs), since the first article till date, a review pertaining to the existence and role of ERs in OSCC was formulated since 1981 till 2018. This is the first review on receptor level genomics in OSCC for three ERα, β, and γ. We have also discussed ERγ, which has been reported in very few reports. The prognostic significance of ERα, β, γ in comparison with other squamous cell carcinoma is tabled.

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