TY - JOUR A1 - Thakare, Eesha A1 - Chaudhary, Minal A1 - Gadbail, Amol T1 - The role of estrogen receptors α, β, γ in oral squamous cell carcinoma and a comparative perspective of squamous cell carcinoma Y1 - 2020/1/1 JF - Indian Journal of Oral Health and Research JO - Indian J Oral Health Res SP - 1 EP - 7 VL - 6 IS - 1 UR - https://www.ijohr.org/article.asp?issn=2393-8692;year=2020;volume=6;issue=1;spage=1;epage=7;aulast=Thakare DO - 10.4103/ijohr.ijohr_3_20 N2 - The “nuclear receptors” (NRs) belong to the huge group of transcription factors, triggered with the help of diverse signal molecules. Various physiological (or pathological) conditions responding to metabolite, hormonal, and nutrient signals lead to the activation of specific gene expression with the help of large number of members of NR superfamily. The role of hormone estrogen as an oncogenic agent is well illustrated in hormone-sensitive carcinomas that include ovarian, colon, endometrial, prostate, lung, and breast. This is the first review on oral squamous cell carcinoma (OSCC) pertaining to Estrogen receptors (ER) like α, β and γ study published in PubMed. For hormone ligand action in head and neck carcinomas (HNCs) specifically, experiments in vivo and in vitro studies support a probable biological mechanism. As per the search in PubMed (search words ERs, OSCC, HNCs), since the first article till date, a review pertaining to the existence and role of ERs in OSCC was formulated since 1981 till 2018. This is the first review on receptor level genomics in OSCC for three ERα, β, and γ. We have also discussed ERγ, which has been reported in very few reports. The prognostic significance of ERα, β, γ in comparison with other squamous cell carcinoma is tabled. ER -